Cholinesterase Inhibition Activity and Molecular Docking Study of Eugenol Derivatives

The study was conducted to explore the anticholinesterase inhibition property of eugenol derived molecules. Ten derivatives were synthesized and evaluated for inhibitory activities against acetylcholinesterase (AChE) butyrylcholinesterase (BChE) by Ellman’s method. Most tested showed higher on BChE than AChE, however, their overall activity weak. In contrast, three (compounds 3,6,9) good AChE more 50% at 10 μg/mL. Among them, compound 9bearing a ethyl substituent para position benzoyl ring most potent inhibition, with IC50 5.64 Ligand-protein docking simulation also performed active molecules 3,6,9).